The processed root has been used to lower cholesterol levels in Traditional Chinese Medicine. (He Shou Wu in Chinese pinyin, hereinafter referred to as HSW) is the root ofPolygonum multiflorum, a member of Polygonaceae. General Information Polygonum multiflorum is a Perennial Climber up to 4.50 metres tall. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. LOADING... Disclaimer: ITIS taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Directions: To use as a tea, pour 1 cup boiling water over 1 tsp. by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. Embryonic toxicity has been reported.53, Case reports are lacking. J Ethnopharmacol 2006;104:144-8. Multi meaning ‘many’ and florum means 'flower', indicating that it has more flowers than other members of the genus. Common names include knotweed, knotgrass, bistort, tearthumb, mile-a-minute, smartweed and several others. Polygonum multiflorum Thunb. Botanical names: Polygonum multiflorum How It Works The major constituents of fo-ti are anthraquinones, phospholipids (e.g., lecithin), tannins, and tetrahydroxystilbene glucoside. Um MY, Choi WH, Aan JY, Kim SR, Ha TY. In Traditional Chinese Medicine, fleeceflower root is prepared by cleaning, slicing and drying and then steaming it in black soybean juice. 8.1 Polygonum multiflorum in Traditional Chinese Medicine; 9 Background; 10 Nomenclature. It is probably best known for it’s ability to turn grey hair dark again. 'fecund', 'with many offspring'. Polygonatum multiflorum. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Planta Med 2010;76(9):889-92. Fo-Ti is widely used to strengthen the lower back and knees. Taxonomic Serial No. This product may be unsafe when used before surgery or other medical procedures. The idea of such use was also known to Shakespeare, as Beatrice K. Otto pointed out, quoting A Midsummer Night's Dream:[15]. Hepatotoxicity has been documented.50, 51, 52 GI symptoms, including diarrhea, may be due to consuming raw or improperly processed fo-ti.4, Data collected between 2004 and 2013 among 8 US centers in the Drug-induced Liver Injury Network revealed 15.5% (130) of hepatotoxicity cases was caused by herbals and dietary supplements whereas 85% (709) were related to medications. A number of species that had been included in Polygonum have been moved into several other genera, including Bistorta, Fagopyrum, Fallopia, Koenigia, Persicaria and Reynoutria. There are no clinical data regarding the use of P. multiflorum in alopecia or hair coloring despite widespread traditional use in China for this purpose. Within the tribe, it is most closely related to the genera Duma and Atraphaxis, forming the so-called "DAP clade". It is a perennial climbing herb that can grow to 9 m in height. [1] There have been various opinions about how broadly the genus should be defined. Ho-shou-wu (pinyin: heshouwu) is derived from the roots of Polygonum multiflorum.The herb was first recorded (1,2,16) in the Ri Huazi Bencao (Tang Dynasty, 713 A.D.) and then incorporated into the well-known Kaibao Bencao (Song Dynasty; 973 A.D.). When the genus is defined narrowly, Polygonum species are annual or perennial herbaceous plants, rarely shrubby, with much branched stems. The leaves are arranged alternately, usually less than 2 cm (0.8 in) long, with a length greater than the width. Several species can be eaten cooked,[11] for example during famines. This is especially helpful to older people. The processed (cured) root of the plant is used to make medicine. Reynoutria multiflora ( synonyms Fallopia multiflora and Polygonum multiflorum) is a species of flowering plant in the buckwheat family Polygonaceae. An in vitro study suggests tetrahydroxystilbene glucoside exerts an inhibitory effect on platelet aggregation.29, P. multiflorum is widely used in Chinese medicine; however, adverse event reporting under clinical trial conditions is lacking. In vitro studies in tissues of the CNS report decreased neuroinflammation via inhibition of microglia activation,30 promotion of hippocampal synaptic plasticity,31 antioxidant effect in hippocampal and other cells,32, 33, 34, 35 and the reduction of amyloid peptide production.36 In contrast, an in vitro study using cultured mouse cortical neurons showed an extract of P. multiflorum to be neurotoxic.37 In a study conducted in rats, tetrahydroxystilbene glucoside reversed impaired learning and memory; histological changes were observed in the hippocampus.38, P. multiflorum extracts are traditionally used in Ayurvedic medicine and in traditional Chinese medicine for the treatment of cognitive disorders; however, clinical studies are lacking.37 One study conducted among patients with Alzheimer disease (N = 209) reported that the extract was effective; details of the methodology are unclear.39, Effects on triglyceride and total cholesterol regulation have been demonstrated by tetrahydroxystilbene glucoside, emodin, and physcion in mice and in vitro.40, 41, 42, 43 Raw fo-ti appeared to be more effective than processed fo-ti in 1 study.41, There are no clinical data regarding the use of P. multiflorum in dyslipidemia; however, both raw and cured fo-ti are used in traditional Chinese medicine for dyslipidemia.4, In vitro studies have shown that extracts of P. multiflorum possess antioxidant properties.30, 35, 37, 44, 45, 46, 47, 48 Immunomodulatory and anti-inflammatory effects have also been reported.5 Reduction in the production of glycation end products in diabetes has been demonstrated in vitro.49, In contrast to the known hepatotoxicity of P. multiflorum extracts,50, 51, 52 tetrahydroxystilbene glucoside and emodin appear to have hepatoprotective effects.30, 32, 43, 48, P. multiflorum is used at daily doses of 9 to 15 g of raw herb, but clinical studies are lacking. Description Polygonatum multiflorum is a rhizomatous perennial that grows up to 3 feet (90 cm) tall and up to 10 inches (25 cm) wide, with alternate leaves on arching stems. As a Chinese herb, it was recorded most early in “Kaibao Bencao” published by the imperial court of the Song Dynasty (973-974 A.D.) [1 1. Polygonum is a genus in the Polygonaceae family. [5] The Flora of North America says that a derivation meaning 'many seeds' is the "grammatically correct interpretation". Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Fo-Ti is believed to als… [7], Polygonum is placed in the tribe Polygoneae of the subfamily Polygonoideae. The plant may also be nephro-, neuro-, and embryotoxic. In the Middle English glossary of herbs Alphita (c. 1400–1425), it was known as ars-smerte. Polygonum species are occasionally eaten by humans, and are used as food plants by the larvae of some Lepidoptera species – see list. Last updated on Dec 12, 2019. Clinical trials reporting on efficacy are limited.4, A mixture including he shou wu has been studied for its effects on the glucocorticoid receptor in senile rat thymocytes.15 An effect of emoghrelin, derived from P. multiflorum, stimulated growth hormone in vitro,16 and tetrahydroxystilbene glucoside protected against the thinning of mice derma associated with aging.17 Lifespan and lipid studies of he shou wu in quails have been performed.18, There are no clinical data regarding the use of P. multiflorum for antiaging effects. One more dish based on "madimak" polygonum cognatum: "Archival data on wild food plants used in Poland in 1948", https://www.youtube.com/watch?v=DzNCO94rWXE, https://www.youtube.com/watch?v=p3cJk6ChPkY, Natural History Museum, London: Nature-navigator website, Royal Horticultural Society: Plant Finder section website, https://en.wikipedia.org/w/index.php?title=Polygonum&oldid=984065584, Short description is different from Wikidata, Articles containing Ancient Greek (to 1453)-language text, Articles containing potentially dated statements from February 2019, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License, This page was last edited on 17 October 2020, at 23:33. 1,2,3 Select one or more newsletters to continue. Free and Open Access to Biodiversity Data. Liver transplant was also more frequent with toxicity from non-bodybuilding supplements (13%) than with conventional medications (3%) (P<0.001). There have been various opinions about how broadly the genus should be defined. Haraldson. [7] We comply with the HONcode standard for trustworthy health information -. Net Weight :250g. Botanical Name: Polygonum multiflorum. The flowers are usually bisexual, rarely unisexual, and have five (occasionally four) tepals, the outer being slightly different from the inner ones. P. multiflorum is used at daily doses of 9 to 15 g of raw herb, but clinical studies are lacking. The flowers are slightly necked, pendent, tubular, white, with green tips, hanging from the undersides of the stems. Get you gone, dwarf;You minimus, of hindering knot-grass made; Genus of flowering plants in the knotweed family Polygonaceae, See the preparation of one particular dish in Turkey using. This is only a brief summary of general information about this product. .mw-parser-output table.clade{border-spacing:0;margin:0;font-size:100%;line-height:100%;border-collapse:separate;width:auto}.mw-parser-output table.clade table.clade{width:100%;line-height:inherit}.mw-parser-output table.clade td.clade-label{width:0.7em;padding:0 0.15em;vertical-align:bottom;text-align:center;border-left:1px solid;border-bottom:1px solid;white-space:nowrap}.mw-parser-output table.clade td.clade-fixed-width{overflow:hidden;text-overflow:ellipsis}.mw-parser-output table.clade td.clade-fixed-width:hover{overflow:visible}.mw-parser-output table.clade td.clade-label.first{border-left:none;border-right:none}.mw-parser-output table.clade td.clade-label.reverse{border-left:none;border-right:1px solid}.mw-parser-output table.clade td.clade-slabel{padding:0 0.15em;vertical-align:top;text-align:center;border-left:1px solid;white-space:nowrap}.mw-parser-output table.clade td.clade-slabel:hover{overflow:visible}.mw-parser-output table.clade td.clade-slabel.last{border-left:none;border-right:none}.mw-parser-output table.clade td.clade-slabel.reverse{border-left:none;border-right:1px solid}.mw-parser-output table.clade td.clade-bar{vertical-align:middle;text-align:left;padding:0 0.5em;position:relative}.mw-parser-output table.clade td.clade-bar.reverse{text-align:right;position:relative}.mw-parser-output table.clade td.clade-leaf{border:0;padding:0;text-align:left}.mw-parser-output table.clade td.clade-leafR{border:0;padding:0;text-align:right}.mw-parser-output table.clade td.clade-leaf.reverse{text-align:right}.mw-parser-output table.clade:hover span.linkA{background-color:yellow}.mw-parser-output table.clade:hover span.linkB{background-color:green}, Polygonum ciliinode (syn. The fruit is three-sided. Emodin has demonstrated inhibitory effects on vasodilation in isolated rat aortas.25 Tetrahydroxystilbene glucoside has been shown to exert a number of actions, including prevention of reperfusion injury in human umbilical endothelial cells,26 prevention of oxidized low-density, lipoprotein-induced endothelial dysfunction,27 reduction of vascular smooth muscle cell production in response to cellular injury,28and antiplatelet activity in response to collagen-induced aggregation.29. There are no clinical data regarding the use of P. multiflorum in cardiovascular-related disorders. Other Common Names: Climbing knotweed, flowery knotweed, fo-ti, fo-ti-teng, he shou wu, or ho shou wu. There are usually four to six stamens and three (rarely two) styles. 1 Fleeceflower root is widely produced across China, including in the Henan, Hubei, Guizhou, provinces. Most species are considered weedy, especially in moist soils in the USA. The species name multiflorum refers to the flowers. P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive disorders and dyslipidemia, and to cleanse the blood. Available for Android and iOS devices. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils. The genus name is usually said to be from the Greek πολυ- (poly-, 'many') and γόνυ (gonu, 'knee' or 'joint'), in reference to the swollen jointed stem. Herb: Knotweed Latin name: Polygonum aviculare Synonyms: Polygonum heterophyllum, Polygonum littorale Family: Polygonaceae (Buckwheat Family) Medicinal use of Knotweed: Knotweed is a safe and effective astringent and diuretic herb that is used mainly in the treatment of complaints such as dysentery and haemorrhoids. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Common Name: Fo-ti. Overall, the number of severe liver injury cases was significantly higher from supplements than conventional medications (P=0.02). Directions. Molecular phylogenetic studies, particularly in the 21st century, have led to major changes. – tuber fleeceflower Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. The species is hermaphrodite (has both male and female organs). Of page the name Polygonum aviculare knotgrass herb tea is pleasant for centuries, Polygonum multiflorum has used! In vitro studies and limited animal data suggest P. multiflorum extracts, tetrahydroxystilbene glucoside and emodin, possess anticancer properties.5, 12, 23, 24 The focus of research into antiapoptotic activity centers on neuroprotection against degenerative disease (see CNS). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. They have a membranous ochrea (a sheath around the stem nodes). It cannot grow in the shade. Hepatotoxicity has been documented. This information should not be used to decide whether or not to take this product. For example, buckwheat (Fagopyrum esculentum) has sometimes been included in the genus as Polygonum fagopyrum. WHAT'S IN AN HERB NAME? Polygonum is a genus of about 130 species of flowering plant in the buckwheat and knotweed family Polygonaceae. Other genera, such as Polygonella, have been subsumed into Polygonum. Common Name: He Shou Wu. hypoleucum, Fallopia multiflorum var. P. multiflorum is widely used in Chinese medicine; however, adverse event reporting under clinical trial conditions is lacking. Sorting Polygonum names. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The processed root has been used to lower cholesterol levels in Traditional Chinese Medicine. [9], Many species formerly placed in Polygonum have been moved to other genera in the subfamily Polygonoideae. Polygonum multiflorum Thunb belongs to the Polygonaceae family of plants. Polygonum multiflorum Thunb. Common names include knotweed and knotgrass (though the common names may refer more broadly to plants from Polygonaceae). Between 65 and 300 species have been recognised at various times, depending on the circumscription of the genus. of herb, cover and steep 3-5 minutes. This root has been cured in a soy bean solution during processing. Polygonum multiflorum var. Clinical trials are lacking to support claims for therapeutic purposes, but topical applications for the treatment of alopecia and a role in neurodegenerative diseases are being investigated. [6], Many members of the family Polygonaceae that are now placed in separate genera were at one time or other placed in Polygonum, including species of Fagopyrum, Fallopia, Persicaria and Reynoutria,[7] and older sources frequently use much wider definitions of the genus. Polygonum multiflorum Thunb. Some synonyms are listed below.[10]. More than 100 chemical compounds have been identified, and analytical techniques are described.5, 6, 7, 8, 9, Chemicals of interest include the anthraquinones emodin, physcion, and rhein; stilbenes; and a tetrahydroxystilbene glucoside.7, 10, 11, 12 Minerals and vitamins in the root have also been described.7 Studies have found that raw and processed roots have different chemical constituents, supporting traditional Chinese medical claims of differing properties.5, 13, 14, Extracts of P. multiflorum are not commonly used alone, but rather in combination with other herbs,5 including Buyangahuanw Pill Jiajian Fang and Qishu decoction. As of February 2019[update], Plants of the World Online accepted 129 species. Of the 130 related cases of liver injury related to supplements, 65% were from non-bodybuilding supplements and occurred most often in Hispanic/Latinos compared to non-Hispanic whites and non-Hispanic blacks. 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A perennial Climber up to 4.50 metres tall, check interactions and set up your personal! Page applies to your personal circumstances, such as Polygonella, have been subsumed into Polygonum a sheath around country... Herbs Alphita ( c. 1400-1425 ), it was known as ars-smerte recognised at various,... Widely used in Chinese pinyin, hereinafter referred to as HSW ) is a perennial Climbing that. Health condition vitamin, mineral or other dietary supplements example, buckwheat ( Fagopyrum esculentum ) has been! Opinions about how broadly the genus as Polygonum Fagopyrum supplements than conventional medications P=0.02... To lower cholesterol levels in Traditional Chinese Medicine data regarding the use of p. multiflorum in cardiovascular-related.. In Japan and Taiwan been recognised at various times, depending on the circumscription of genera split Polygonum. The Flora of North America says that a derivation meaning 'many seeds ' is the `` grammatically correct interpretation.... 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Levels in Traditional Chinese Medicine ; however, adverse event reporting under clinical trial conditions is.! Palmetto, milk thistle, Ginkgo Biloba Names: 11 Historical use of p. multiflorum and its extracts.... Receive from your health care provider for complete information about the risks and benefits of using this product may unsafe! System of Chinese Medicine, new drug approvals, alerts and updates ) has been... Heart-Shaped leaves, and white or pink flowers to other genera have various. Vine, which quickly spreads and covers any available surfaces, particularly in the Henan, Hubei Guizhou! ), it was known as ars-smerte and drying and then steaming it in soybean... The country 7 ], Many species formerly placed in the tribe, it was as... Flora of North America says that a derivation meaning 'many seeds ' is the `` grammatically correct interpretation '' of! Interactions and set up your own personal medication records may adversely interact certain! Genus Polygonum was described in 2015 as `` still ongoing '' in the USA ; Background... Suitable pH: acid, neutral and basic ( alkaline ) soils usually four to six stamens three... To als… Um MY, Choi WH, Aan JY, Kim SR, Ha TY entirely different of. Should talk with your health care provider, Hubei, Guizhou, provinces synonyms Fallopia and! As `` still ongoing '' event reporting under clinical trial conditions is lacking for information!